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Hydrophobic residues of melittin mediate its binding to αA−crystallin

The molecular chaperone αA‐crystallin, mainly localized in the human ocular lens, is believed to protect the lens from opacification and cataract, by suppressing the aggregation of the other lens proteins. The present study provides structural and thermodynamic insights into the ability of human αA‐...

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Détails bibliographiques
Publié dans:Protein Sci
Auteurs principaux: Ramirez, Lisa M., Shekhtman, Alexander, Pande, Jayanti
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Inc. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954717/
https://ncbi.nlm.nih.gov/pubmed/31762096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3792
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