Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

BACKGROUND: Microglial activation is a prominent feature of neuroinflammation, which is present in almost all neurodegenerative diseases. While an initial inflammatory response mediated by microglia is considered to be protective, excessive pro-inflammatory response of microglia contributes to the p...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Ye, Xiaoxia, Zhu, Mingming, Che, Xiaohang, Wang, Huiyang, Liang, Xing-Jie, Wu, Chunfu, Xue, Xue, Yang, Jingyu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954631/
https://ncbi.nlm.nih.gov/pubmed/31926553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1644-8
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