SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages

Sirtuins 1 and 2 (SIRT1/2) are two NAD-dependent deacetylases with major roles in inflammation. In addition to deacetylating histones and other proteins, SIRT1/2-mediated regulation is coupled with other epigenetic enzymes. Here, we investigate the links between SIRT1/2 activity and DNA methylation...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Li, Tianlu, Garcia-Gomez, Antonio, Morante-Palacios, Octavio, Ciudad, Laura, Özkaramehmet, Sevgi, Van Dijck, Evelien, Rodríguez-Ubreva, Javier, Vaquero, Alejandro, Ballestar, Esteban
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954413/
https://ncbi.nlm.nih.gov/pubmed/31799621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1127
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