Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

Despite the rapid development of CRISPR/Cas9-mediated gene editing technology, the gene editing potential of CRISPR/Cas9 is hampered by low efficiency, especially for clinical applications. One of the major challenges is that chromatin compaction inevitably limits the Cas9 protein access to the targ...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Liu, Bin, Chen, Siwei, Rose, Anouk La, Chen, Deng, Cao, Fangyuan, Zwinderman, Martijn, Kiemel, Dominik, Aïssi, Manon, Dekker, Frank J, Haisma, Hidde J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954403/
https://ncbi.nlm.nih.gov/pubmed/31799598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1136
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