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In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription

Molecular barcoding technologies that uniquely identify single cells are hampered by limitations in barcode measurement. Readout by sequencing does not preserve the spatial organization of cells in tissues, whereas imaging methods preserve spatial structure but are less sensitive to barcode sequence...

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Detalles Bibliográficos
Publicado en:Nat Biotechnol
Main Authors: Askary, Amjad, Sanchez-Guardado, Luis, Linton, James M., Chadly, Duncan M., Budde, Mark W., Cai, Long, Lois, Carlos, Elowitz, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954335/
https://ncbi.nlm.nih.gov/pubmed/31740838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0299-4
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