ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer

TGF-β is an important tumor suppressor in pancreatic ductal adenocarcinoma (PDA), yet inactivation of TGF-β pathway components occurs in only half of PDA cases. TGF-β cooperates with oncogenic RAS signaling to trigger epithelial-mesenchymal transition (EMT) in pre-malignant pancreatic epithelial pro...

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Udgivet i:Cancer Discov
Main Authors: Huang, Yun-Han, Hu, Jing, Chen, Fei, Lecomte, Nicolas, Basnet, Harihar, David, Charles J., Witkin, Matthew D., Allen, Peter J., Leach, Steven D., Hollmann, Travis J., Iacobuzio-Donahue, Christine A., Massagué, Joan
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954299/
https://ncbi.nlm.nih.gov/pubmed/31582374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0529
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