Pharmacological inhibition of Glycogen Synthase Kinase 3 increases operant alcohol self-administration in a manner associated with altered pGSK-3β, PICK1 and GluA2 protein expression in the reward pathway of male C57BL/6J mice

Glycogen synthase kinase 3 (GSK-3) is a constitutively active serine-threonine kinase that regulates numerous signaling pathways and has been implicated in neurodegenerative and neuropsychiatric diseases including Alzheimer’s, Parkinson’s, schizophrenia, and bipolar disorder. Evidence indicates that...

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Détails bibliographiques
Publié dans:Behav Pharmacol
Auteurs principaux: Faccidomo, Sara, Holstein, Sarah E, Santanam, Taruni S, Saunders, Briana L., Swaim, Katarina S., Reid, Grant T, O’Neill, Conor, Eastman, Vallari R, Hodge, Clyde W
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954298/
https://ncbi.nlm.nih.gov/pubmed/31503067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0000000000000501
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