Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice

Adenoviral (Ad) vectors represent promising vaccine platforms for infectious disease. To overcome pre-existing immunity to commonly used human adenovirus serotype 5 (Ad5), vectors based on rare species or non-human Ads are being developed. However, these vectors often exhibit reduced potency compare...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Bliss, Carly M., Parsons, Andrea J., Nachbagauer, Raffael, Hamilton, Jennifer R., Cappuccini, Federica, Ulaszewska, Marta, Webber, Jason P., Clayton, Aled, Hill, Adrian V.S., Coughlan, Lynda
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953706/
https://ncbi.nlm.nih.gov/pubmed/31934599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.12.003
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