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Immunogenicity and efficacy of the novel cancer vaccine based on simian adenovirus and MVA vectors alone and in combination with PD-1 mAb in a mouse model of prostate cancer

Prostate cancer possesses several characteristics that make it a suitable candidate for immunotherapy; however, prostate cancer vaccines to date demonstrate modest efficacy and low immunogenicity. The goal of the present pre-clinical study was to explore the immunogenic properties and protective eff...

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Détails bibliographiques
Publié dans:Cancer Immunol Immunother
Auteurs principaux: Cappuccini, Federica, Stribbling, Stephen, Pollock, Emily, Hill, Adrian V. S., Redchenko, Irina
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880633/
https://ncbi.nlm.nih.gov/pubmed/27052571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1831-8
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