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SCN8A encephalopathy: Mechanisms and Models
De novo mutations of the neuronal sodium channel SCN8A have been identified in approximately 2% of individuals with epileptic encephalopathy. These missense mutations alter the biophysical properties of sodium channel Nav1.6 in ways that lead to neuronal hyperexcitability. We generated two mouse mod...
Gardado en:
| Publicado en: | Epilepsia |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6953611/ https://ncbi.nlm.nih.gov/pubmed/31904118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14703 |
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