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Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes

Both intercellular signaling and epigenetic mechanisms regulate embryonic development, but it is unclear how they are integrated to establish and maintain lineage-specific gene expression programs. Here, we show that a key function of the developmentally essential Nodal-Smads2/3 (Smad2 and Smad3) si...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Dahle, Øyvind, Kumar, Amit, Kuehn, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953396/
https://ncbi.nlm.nih.gov/pubmed/20571128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000841
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