Isotalatizidine, a C(19)-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression

BACKGROUND: Isotalatizidine is a representative C(19)-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheumatic, and immunosuppressive properties. The aim of this...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Shao, Shuai, Xia, Huan, Hu, Min, Chen, Chengjuan, Fu, Junmin, Shi, Gaona, Guo, Qinglan, Zhou, Yu, Wang, Wenjie, Shi, Jiangong, Zhang, Tiantai
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953278/
https://ncbi.nlm.nih.gov/pubmed/31924228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1696-9
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