Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2(V617F) against myeloproliferative neoplasms

BACKGROUND: The JAK2-STAT signaling pathway plays a critical role in myeloproliferative neoplasms (MPN). An activating mutation in JAK2 (V617F) is present in ~ 95% of polycythemia vera, essential thrombocythemia, and primary myelofibrosis cases. This study aims to explore the selective JAK2(V617F) i...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Hu, Min, Xu, Chengbo, Yang, Chao, Zuo, Hongli, Chen, Chengjuan, Zhang, Dan, Shi, Gaona, Wang, Wenjie, Shi, Jiangong, Zhang, Tiantai
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360668/
https://ncbi.nlm.nih.gov/pubmed/30717771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1062-x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados