Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells

Background: Mutations in genes encoding intercalated disk/desmosome proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (ACM). Desmosomes are responsible for myocyte–myocyte attachment and maintaining mechanical integrity of the myocardium. Methods: We knocked down Pkp2 in HL...

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Udgivet i:Cells
Main Authors: Puzzi, Luca, Borin, Daniele, Gurha, Priyatansh, Lombardi, Raffaella, Martinelli, Valentina, Weiss, Marek, Andolfi, Laura, Lazzarino, Marco, Mestroni, Luisa, Marian, Ali J., Sbaizero, Orfeo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952926/
https://ncbi.nlm.nih.gov/pubmed/31847412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121639
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