Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion

NF-κB and Notch signaling can be simultaneously activated in a variety of B-cell lymphomas. Patients with B-cell lymphoma occasionally develop clonally related myeloid tumors with poor prognosis. Whether concurrent activation of both pathways is sufficient to induce B-cell transformation and whether...

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Vydáno v:Blood
Hlavní autoři: Xiu, Yan, Dong, Qianze, Fu, Lin, Bossler, Aaron, Tang, Xiaobing, Boyce, Brendan, Borcherding, Nicholas, Leidinger, Mariah, Sardina, José Luis, Xue, Hai-hui, Li, Qingchang, Feldman, Andrew, Aifantis, Iannis, Boccalatte, Francesco, Wang, Lili, Jin, Meiling, Khoury, Joseph, Wang, Wei, Hu, Shimin, Yuan, Youzhong, Wang, Endi, Yuan, Ji, Janz, Siegfried, Colgan, John, Habelhah, Hasem, Waldschmidt, Thomas, Müschen, Markus, Bagg, Adam, Darbro, Benjamin, Zhao, Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952829/
https://ncbi.nlm.nih.gov/pubmed/31697816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001438
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