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RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival

Although TRAIL is considered a potential anticancer agent, it enhances tumor progression by activating NF-κB in apoptosis-resistant cells. Cellular FLICE-like inhibitory protein (cFLIP) overexpression and caspase-8 activation have been implicated in TRAIL-induced NF-κB activation; however, the under...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Zhang, Laiqun, Blackwell, Ken, Workman, Lauren M., Chen, Songhai, Pope, Marshall R., Janz, Siegfried, Habelhah, Hasem
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561725/
https://ncbi.nlm.nih.gov/pubmed/26195820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00692-15
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