Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure of the viral ssRNA genome to endosomal Toll-like receptors (TLRs). TLRs are instrumental in activating inflammatory responses in innate immune cells, but their funct...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Meås, Hany Zekaria, Haug, Markus, Beckwith, Marianne Sandvold, Louet, Claire, Ryan, Liv, Hu, Zhenyi, Landskron, Johannes, Nordbø, Svein Arne, Taskén, Kjetil, Yin, Hang, Damås, Jan Kristian, Flo, Trude Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952430/
https://ncbi.nlm.nih.gov/pubmed/31919342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13837-4
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