No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

The No-Go Decay (NGD) mRNA surveillance pathway degrades mRNAs containing stacks of stalled ribosomes. Although an endoribonuclease has been proposed to initiate cleavages upstream of the stall sequence, the production of two RNA fragments resulting from a unique cleavage has never been demonstrated...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Navickas, Albertas, Chamois, Sébastien, Saint-Fort, Rénette, Henri, Julien, Torchet, Claire, Benard, Lionel
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949252/
https://ncbi.nlm.nih.gov/pubmed/31913314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13991-9
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