β-arrestin2 alleviates L-dopa–induced dyskinesia via lower D1R activity in Parkinson’s rats

The cause of the L-dopa–induced dyskinesia (LID) has been ascribed to G-protein coupled receptor (GPCR) supersensitivity and uncontrolled downstream signaling. It is now supposed that β-arrestin2 affects GPCR signaling through its ability to scaffold various intracellular molecules. We used the rAAV...

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Podrobná bibliografie
Vydáno v:Aging (Albany NY)
Hlavní autoři: Zhang, Xing-Ru, Zhang, Zeng-Rui, Chen, Si-Yan, Wang, Wen-Wen, Wang, Xin-Shi, He, Jin-Cai, Xie, Cheng-Long
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949085/
https://ncbi.nlm.nih.gov/pubmed/31891566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102574
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