Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia

Anemia of β-thalassemia is caused by ineffective erythropoiesis and reduced red cell survival. Several lines of evidence indicate that iron/heme restriction is a potential therapeutic strategy for the disease. Glycine is a key initial substrate for heme and globin synthesis. We provide evidence that...

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Publicat a:JCI Insight
Autors principals: Matte, Alessandro, Federti, Enrica, Winter, Michael, Koerner, Annette, Harmeier, Anja, Mazer, Norman, Tomka, Tomas, Di Paolo, Maria Luisa, Defalco, Luigia, Andolfo, Immacolata, Beneduce, Elisabetta, Iolascon, Achille, Macias-Garcia, Alejandra, Chen, Jane-Jane, Janin, Anne, Lebouef, Christhophe, Turrini, Franco, Brugnara, Carlo, De Franceschi, Lucia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948868/
https://ncbi.nlm.nih.gov/pubmed/31593554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130111
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