Investigation of a dilated cardiomyopathy–associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes

Mutations in B cell lymphoma 2–associated athanogene 3 (BAG3) are recurrently associated with dilated cardiomyopathy (DCM) and muscular dystrophy. Using isogenic genome-edited human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs), we examined how a DCM-causing BAG3 mutation (R477H),...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: McDermott-Roe, Chris, Lv, Wenjian, Maximova, Tania, Wada, Shogo, Bukowy, John, Marquez, Maribel, Lai, Shuping, Shehu, Amarda, Benjamin, Ivor, Geurts, Aron, Musunuru, Kiran
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948852/
https://ncbi.nlm.nih.gov/pubmed/31723063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128799
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