TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy

Lysosomes are at the epicenter of cellular processes critical for inflammasome activation in macrophages. Inflammasome activation and IL-1β secretion are implicated in myocardial infarction (MI) and resultant heart failure; however, little is known about how macrophage lysosomes regulate these proce...

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Vydáno v:JCI Insight
Hlavní autoři: Javaheri, Ali, Bajpai, Geetika, Picataggi, Antonino, Mani, Smrithi, Foroughi, Layla, Evie, Hosannah, Kovacs, Attila, Weinheimer, Carla J., Hyrc, Krzystztof, Xiao, Qingli, Ballabio, Andrea, Lee, Jin-Moo, Matkovich, Scot J., Razani, Babak, Schilling, Joel D., Lavine, Kory J., Diwan, Abhinav
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948771/
https://ncbi.nlm.nih.gov/pubmed/31672943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127312
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