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Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance

The epidermal growth factor receptor inhibitor cetuximab is the only oncogene-targeted agent that has been FDA approved for the treatment of head and neck squamous cell carcinoma (HNSCC). Currently, there are no biomarkers used in the clinic to predict which HNSCC tumors will respond to cetuximab, a...

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Publicado en:PLoS One
Autores principales: O’Keefe, Rachel A., Bhola, Neil E., Lee, David S., Johnson, Daniel E., Grandis, Jennifer R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948745/
https://ncbi.nlm.nih.gov/pubmed/31914141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227261
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