Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

The presence of disseminated tumour cells (DTCs) in BM predicts poorer metastasis-free survival of breast cancer patients with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume this is because the majority of DTCs are quiescent....

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Publicado no:Nat Cell Biol
Main Authors: Carlson, Patrick, Dasgupta, Arko, Grzelak, Candice A., Kim, Jeanna, Barrett, Alexander, Coleman, Ilsa M., Shor, Ryann E., Goddard, Erica T., Dai, Jinxiang, Schweitzer, Emma M., Lim, Andrea R., Crist, Sarah B., Cheresh, David A., Nelson, Peter S., Hansen, Kirk C., Ghajar, Cyrus M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948102/
https://ncbi.nlm.nih.gov/pubmed/30664790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0267-0
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