A pre-existing population of ZEB2(+) quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

BACKGROUND: Quiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations and the molecular factors linking quiescence to chemoresistance are largely unknown. METHODS: A population of chemoresistant qui...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Francescangeli, Federica, Contavalli, Paola, De Angelis, Maria Laura, Careccia, Silvia, Signore, Michele, Haas, Tobias Longin, Salaris, Federico, Baiocchi, Marta, Boe, Alessandra, Giuliani, Alessandro, Tcheremenskaia, Olga, Pagliuca, Alfredo, Guardiola, Ombretta, Minchiotti, Gabriella, Colace, Lidia, Ciardi, Antonio, D’Andrea, Vito, La Torre, Filippo, Medema, JanPaul, De Maria, Ruggero, Zeuner, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6947904/
https://ncbi.nlm.nih.gov/pubmed/31910865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1505-4
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