Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels. However, it is very challenging to deliver miRNAs directly, which leads to inactivation, low transfection efficiency, and short h...

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Detalles Bibliográficos
Publicado en:Adv Sci (Weinh)
Main Authors: Chen, Wei, Chen, Hao, Zheng, Dandan, Zhang, Hongbo, Deng, Lianfu, Cui, Wenguo, Zhang, Yuhui, Santos, Hélder A., Shen, Hongxing
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6947697/
https://ncbi.nlm.nih.gov/pubmed/31921568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201902099
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