Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels. However, it is very challenging to deliver miRNAs directly, which leads to inactivation, low transfection efficiency, and short h...

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Vydáno v:Adv Sci (Weinh)
Hlavní autoři: Chen, Wei, Chen, Hao, Zheng, Dandan, Zhang, Hongbo, Deng, Lianfu, Cui, Wenguo, Zhang, Yuhui, Santos, Hélder A., Shen, Hongxing
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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Full Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6947697/
https://ncbi.nlm.nih.gov/pubmed/31921568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201902099
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