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Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from short half‐lives and limited efficacy across the b...

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Detalhes bibliográficos
Publicado no:Adv Sci (Weinh)
Main Authors: Zhang, Libin, Baker, Stefanie L., Murata, Hironobu, Harris, Nicholas, Ji, Weihang, Amitai, Gabriel, Matyjaszewski, Krzysztof, Russell, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6947490/
https://ncbi.nlm.nih.gov/pubmed/31921563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201901904
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