Quantitative high-throughput screening using an organotypic model identifies compounds that inhibit ovarian cancer metastasis

The tumor microenvironment (TME) is a key determinant of metastatic efficiency. We performed a quantitative high throughput screen (qHTS) of diverse medicinal-chemistry tractable scaffolds (44,420 compounds) and pharmacologically active small molecules (386 compounds) using a layered organotypic, ro...

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Pubblicato in:Mol Cancer Ther
Autori principali: Kenny, Hilary A., Lal-Nag, Madhu, Shen, Min, Kara, Betul, Nahotko, Dominik A., Wroblewski, Kristen, Fazal, Sarah, Chen, Siquan, Chiang, Chun-Yi, Chen, Yen-Ju, Brimacombe, Kyle R., Marugan, Juan, Ferrer, Marc, Lengyel, Ernst
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946883/
https://ncbi.nlm.nih.gov/pubmed/31562255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0052
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