Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows tha...

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Publicado no:Nat Commun
Main Authors: Kachuri, Linda, Johansson, Mattias, Rashkin, Sara R., Graff, Rebecca E., Bossé, Yohan, Manem, Venkata, Caporaso, Neil E., Landi, Maria Teresa, Christiani, David C., Vineis, Paolo, Liu, Geoffrey, Scelo, Ghislaine, Zaridze, David, Shete, Sanjay S., Albanes, Demetrius, Aldrich, Melinda C., Tardón, Adonina, Rennert, Gad, Chen, Chu, Goodman, Gary E., Doherty, Jennifer A., Bickeböller, Heike, Field, John K., Davies, Michael P., Dawn Teare, M., Kiemeney, Lambertus A., Bojesen, Stig E., Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Le Marchand, Loïc, Cheng, Iona, Schabath, Matthew B., Duell, Eric J., Andrew, Angeline S., Manjer, Jonas, Lazarus, Philip, Arnold, Susanne, McKay, James D., Emami, Nima C., Warkentin, Matthew T., Brhane, Yonathan, Obeidat, Ma’en, Martin, Richard M., Relton, Caroline, Davey Smith, George, Haycock, Philip C., Amos, Christopher I., Brennan, Paul, Witte, John S., Hung, Rayjean J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946810/
https://ncbi.nlm.nih.gov/pubmed/31911640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13855-2
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