Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci

DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Dai, Juncheng, Li, Zhihua, Amos, Christopher I, Hung, Rayjean J, Tardon, Adonina, Andrew, Angeline S, Chen, Chu, Christiani, David C, Albanes, Demetrios, van der Heijden, Erik H F M, Duell, Eric J, Rennert, Gad, Mckay, James D, Yuan, Jian-Min, Field, John K, Manjer, Jonas, Grankvist, Kjell, Le Marchand, Loic, Teare, M Dawn, Schabath, Matthew B, Aldrich, Melinda C, Tsao, Ming-Sound, Lazarus, Philip, Lam, Stephen, Bojesen, Stig E, Arnold, Susanne, Wu, Xifeng, Haugen, Aage, Janout, Vladimir, Johansson, Mikael, Brhane, Yonathan, Fernandez-Somoano, Ana, Kiemeney, Lambertus A, Davies, Michael P A, Zienolddiny, Shanbeh, Hu, Zhibin, Shen, Hongbing
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cancer Biomarkers and Molecular Epidemiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783905/
https://ncbi.nlm.nih.gov/pubmed/30590402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy187
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