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PTEN loss in the continuum of common cancers, rare syndromes and mouse models
PTEN is among the most frequently inactivated tumour suppressor genes in sporadic cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor activity is dependent on its lipid phosphatase activity, which negatively regulates the PI3K–AKT–mTOR pathway(1,2). Germline mutat...
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| Опубликовано в: : | Nat Rev Cancer |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6946181/ https://ncbi.nlm.nih.gov/pubmed/21430697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3037 |
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