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PTEN loss in the continuum of common cancers, rare syndromes and mouse models

PTEN is among the most frequently inactivated tumour suppressor genes in sporadic cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor activity is dependent on its lipid phosphatase activity, which negatively regulates the PI3K–AKT–mTOR pathway(1,2). Germline mutat...

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Detalhes bibliográficos
Publicado no:Nat Rev Cancer
Main Authors: Hollander, M. Christine, Blumenthal, Gideon M., Dennis, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946181/
https://ncbi.nlm.nih.gov/pubmed/21430697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3037
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