Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration

Cardiac dysautonomia is a common nonmotor symptom of Parkinson’s disease (PD) associated with loss of sympathetic innervation to the heart and decreased plasma catecholamines. Disease-modifying strategies for PD cardiac neurodegeneration are not available, and biomarkers of target engagement are lac...

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Vydáno v:PLoS One
Hlavní autoři: Metzger, Jeanette M., Matsoff, Helen N., Zinnen, Alexandra D., Fleddermann, Rachel A., Bondarenko, Viktoriya, Simmons, Heather A., Mejia, Andres, Moore, Colleen F., Emborg, Marina E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946159/
https://ncbi.nlm.nih.gov/pubmed/31910209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226999
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