Perlecan/Hspg2 deficiency impairs bone’s calcium signaling and associated transcriptome in response to mechanical loading

Perlecan, a heparan sulfate proteoglycan, acts as a mechanical sensor for bone to detect external loading. Deficiency of perlecan increases the risk of osteoporosis in patients with Schwartz-Jampel Syndrome (SJS) and attenuates loading-induced bone formation in perlecan deficient mice (Hypo). Consid...

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Bibliografiske detaljer
Udgivet i:Bone
Main Authors: Pei, Shaopeng, Parthasarathy, Sucharitha, Parajuli, Ashutosh, Martinez, Jerahme, Lv, Mengxi, Jiang, Sida, Wu, Danielle, Wei, Shuo, Lu, X. Lucas, Farach-Carson, Mary C., Kirn-Safran, Catherine B., Wang, Liyun
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945981/
https://ncbi.nlm.nih.gov/pubmed/31715337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.115078
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