Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome

BACKGROUND: Endocrine-cerebro-osteodysplasia (ECO) syndrome is a genetic disorder associated with congenital defects of the endocrine, cerebral, and skeletal systems in humans. ECO syndrome is caused by mutations of the intestinal cell kinase (ICK) gene, which encodes a mitogen-activated protein (MA...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Shin, Jeong-Oh, Song, Jieun, Choi, Han Seul, Lee, Jisu, Lee, Kyeong, Ko, Hyuk Wan, Bok, Jinwoong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945271/
https://ncbi.nlm.nih.gov/pubmed/31662288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.016
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