Human Biodistribution and Radiation Dosimetry of (18)F-Clofarabine, a PET Probe Targeting the Deoxyribonucleoside Salvage Pathway

(18)F-clofarabine, a nucleotide purine analog, is a substrate for deoxycytidine kinase (dCK), a key enzyme in the deoxyribonucleoside salvage pathway. (18)F-clofarabine might be used to measure dCK expression and thus serve as a predictive biomarker for tumor responses to dCK-dependent prodrugs or s...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Barrio, Martin J., Spick, Claudio, Radu, Caius G., Lassmann, Michael, Eberlein, Uta, Allen-Auerbach, Martin, Schiepers, Christiaan, Slavik, Roger, Czernin, Johannes, Herrmann, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945110/
https://ncbi.nlm.nih.gov/pubmed/27811125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.182394
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