Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme

Glioblastoma multiforme (GBM) is an incurable primary brain tumor containing a sub-population of cancer stem cells (CSCs). Polycomb Repressive Complex (PRC) proteins BMI1 and EZH2 are enriched in CSCs, promoting clonogenic growth and resistance to genotoxic therapies. We report here that when used a...

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Bibliographic Details
Published in:NPJ Precis Oncol
Main Authors: Flamier, Anthony, Abdouh, Mohamed, Hamam, Rimi, Barabino, Andrea, Patel, Niraj, Gao, Andy, Hanna, Roy, Bernier, Gilbert
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944693/
https://ncbi.nlm.nih.gov/pubmed/31934644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-019-0106-1
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