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THAP11(F80L) cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation

Twelve human THAP proteins share the THAP domain, an evolutionary conserved zinc-finger DNA-binding domain. Studies of different THAP proteins have indicated roles in gene transcription, cell proliferation and development. We have analyzed this protein family, focusing on THAP7 and THAP11. We show t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dehaene, Harmonie, Praz, Viviane, Lhôte, Philippe, Lopes, Maykel, Herr, Winship
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944463/
https://ncbi.nlm.nih.gov/pubmed/31905202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224646
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