Analysis of the CYP1A1 mRNA Dose-Response in Human Keratinocytes Indicates that Relative Potencies of Dioxins, Furans, and PCBs Are Species and Congener Specific

Reports indicate that toxic equivalency factors (TEFs) based primarily on rodent data do not accurately predict in vitro human responsiveness to certain dioxin-like chemicals (DLCs). To investigate this in cells responsive to dioxins and relevant to chloracne, normal human epidermal keratinocytes we...

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Detalles Bibliográficos
Publicado en:Toxicol Sci
Main Authors: Sutter, Carrie H., Bodreddigari, Sridevi, Sutter, Thomas R., Carlson, Erik A., Silkworth, Jay B.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
Risk Assessment
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944437/
https://ncbi.nlm.nih.gov/pubmed/20819910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq262
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