Relative effect potency estimates of dioxin-like activity for dioxins, furans, and dioxin-like PCBs in adults based on cytochrome P450 1A1 and 1B1 gene expression in blood

BACKGROUND: In the risk assessment of PCDDs, PCDFs, and dioxin-like (DL) PCBs, regulatory authorities support the use of the toxic equivalency factor (TEF)-scheme derived from a heterogeneous data set of the relative effect potency (REPs) estimates. OBJECTIVES: We sought to determine REPs for dioxin...

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Detalhes bibliográficos
Publicado no:Environ Int
Main Authors: Wimmerová, Soňa, van den Berg, Martin, Chovancová, Jana, Patayová, Henrieta, Jusko, Todd A., van Duursen, Majorie B.M., Murínová, Ľubica Palkovičová, Canton, Rocio F., van Ede, Karin I., Trnovec, Tomáš
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047354/
https://ncbi.nlm.nih.gov/pubmed/27588699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.envint.2016.08.016
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