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The Meta-Position of Phe(4) in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors
As tool compounds to study cardiac ischemia, the endogenous δ-opioid receptors (δOR) agonist Leu(5)-enkephalin and the more metabolically stable synthetic peptide (d-Ala(2), d-Leu(5))-enkephalin are frequently employed. However, both peptides have similar pharmacological profiles that restrict detai...
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| 出版年: | Molecules |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6943441/ https://ncbi.nlm.nih.gov/pubmed/31842282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244542 |
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