The Meta-Position of Phe(4) in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors

As tool compounds to study cardiac ischemia, the endogenous δ-opioid receptors (δOR) agonist Leu(5)-enkephalin and the more metabolically stable synthetic peptide (d-Ala(2), d-Leu(5))-enkephalin are frequently employed. However, both peptides have similar pharmacological profiles that restrict detai...

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Veröffentlicht in:Molecules
Hauptverfasser: Cassell, Robert J., Sharma, Krishna K., Su, Hongyu, Cummins, Benjamin R., Cui, Haoyue, Mores, Kendall L., Blaine, Arryn T., Altman, Ryan A., van Rijn, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943441/
https://ncbi.nlm.nih.gov/pubmed/31842282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244542
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