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Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, inclu...

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書目詳細資料
發表在:Molecules
Main Authors: Aguiar, Luísa, Biosca, Arnau, Lantero, Elena, Gut, Jiri, Vale, Nuno, Rosenthal, Philip J., Nogueira, Fátima, Andreu, David, Fernàndez-Busquets, Xavier, Gomes, Paula
格式: Artigo
語言:Inglês
出版: MDPI 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943437/
https://ncbi.nlm.nih.gov/pubmed/31842498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244559
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