Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, inclu...

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Xehetasun bibliografikoak
Argitaratua izan da:Molecules
Egile Nagusiak: Aguiar, Luísa, Biosca, Arnau, Lantero, Elena, Gut, Jiri, Vale, Nuno, Rosenthal, Philip J., Nogueira, Fátima, Andreu, David, Fernàndez-Busquets, Xavier, Gomes, Paula
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943437/
https://ncbi.nlm.nih.gov/pubmed/31842498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244559
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