Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, inclu...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Aguiar, Luísa, Biosca, Arnau, Lantero, Elena, Gut, Jiri, Vale, Nuno, Rosenthal, Philip J., Nogueira, Fátima, Andreu, David, Fernàndez-Busquets, Xavier, Gomes, Paula
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943437/
https://ncbi.nlm.nih.gov/pubmed/31842498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244559
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