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Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice

Acetaminophen (APAP) overdose–induced hepatotoxicity is the leading cause of drug-induced liver injury worldwide. The related injury pathogenesis is mainly focused on the liver. Here, the authors report that gut barrier disruption may also be involved in APAP hepatotoxicity. APAP administration led...

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Foilsithe in:Am J Pathol
Main Authors: Niu, Mengwei, Luo, Zhihong, Gong, Shenhai, Win, Sanda, Kaplowitz, Neil, Jiang, Yong, Chen, Peng
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Investigative Pathology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943379/
https://ncbi.nlm.nih.gov/pubmed/31610172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.09.009
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