Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action

BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain...

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Detalles Bibliográficos
Publicado en:Diabetes Metab J
Main Authors: Kim, Hong Il, Lee, Ji Seon, Kwak, Byung Kook, Hwang, Won Min, Kim, Min Joo, Kim, Young-Bum, Chung, Sung Soo, Park, Kyong Soo
Formato: Artigo
Idioma:Inglês
Publicado: Korean Diabetes Association 2019
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943256/
https://ncbi.nlm.nih.gov/pubmed/31339010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4093/dmj.2018.0179
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