MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation

Mutations in the mitochondrial DNA (mtDNA) are responsible for several metabolic disorders, commonly involving muscle and the central nervous system(1). Because of the critical role of mtDNA in oxidative phosphorylation, the majority of pathogenic mtDNA mutations are heteroplasmic, co-existing with...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Bacman, Sandra R., Kauppila, Johanna H. K., Pereira, Claudia V., Nissanka, Nadee, Miranda, Maria, Pinto, Milena, Williams, Sion L., Larsson, Nils-Göran, Stewart, James B., Moraes, Carlos T.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942693/
https://ncbi.nlm.nih.gov/pubmed/30250143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0166-8
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