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An Adaptive Trial Design to Optimize Dose-Schedule Regimes with Delayed Outcomes
This paper proposes a two-stage phase I-II clinical trial design to optimize dose–schedule regimes of an experimental agent within ordered disease subgroups in terms of toxicity–efficacy tradeoff. The design is motivated by settings where prior biological information indicates it is certain that eff...
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| Publicado no: | Biometrics |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942642/ https://ncbi.nlm.nih.gov/pubmed/31273750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.13116 |
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