Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in PTEN and dysregulation of innate immune signaling. Here we demonstrate that Rab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate of the innate immune signaling kinases TBK1/IK...

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Vydáno v:Cancer Res
Hlavní autoři: Ritter, Jessica L., Zhu, Zehua, Thai, Tran C., Mahadevan, Navin R., Mertins, Philipp, Knelson, Erik H., Piel, Brandon P., Han, Saemi, Jaffe, Jacob D., Carr, Steven A., Barbie, David A., Barbie, Thanh U.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942622/
https://ncbi.nlm.nih.gov/pubmed/31662325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1310
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