Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in PTEN and dysregulation of innate immune signaling. Here we demonstrate that Rab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate of the innate immune signaling kinases TBK1/IK...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ritter, Jessica L., Zhu, Zehua, Thai, Tran C., Mahadevan, Navin R., Mertins, Philipp, Knelson, Erik H., Piel, Brandon P., Han, Saemi, Jaffe, Jacob D., Carr, Steven A., Barbie, David A., Barbie, Thanh U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942622/
https://ncbi.nlm.nih.gov/pubmed/31662325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1310
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