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Upregulation of p53 through Induction of MDM2 Degradation: Amino Acid Prodrugs of Anthraquinone Analogs
Previously, we reported a class of MDM2-MDM4 dimerization inhibitors that upregulate p53 and showed potent anticancer activity in animal models. However, water solubility hinders their further development. Herein we describe our effort to develop a prodrug approach that overcomes solubility problem....
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942214/ https://ncbi.nlm.nih.gov/pubmed/31753697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126786 |
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